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Metagenomics of the human microbiome

Authors
  • Shestakov, S. V.1, 2
  • 1 Russian Academy of Sciences, Vavilov Institute of General Genetics, Moscow, Russia , Moscow (Russia)
  • 2 Russia Moscow State University, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
SP MAIK Nauka/Interperiodica
Publication Date
Mar 01, 2011
Volume
1
Issue
2
Pages
83–93
Identifiers
DOI: 10.1134/S2079086411020095
Source
Springer Nature
Keywords
License
Yellow

Abstract

Humans are “superorganisms” possessing an “extended genome” of millions of microbial genes that influence the host metabolism and physiology. Metagenomic methods allow the study of the structure and functions of all genes involved in integral gene-metabolic networks of ecologically dynamic microbial communities. This review summarizes some of the latest knowledge obtained by the metagenomic analysis of human gut and oral microbiota and concerns mechanisms of microbiome evolution. The nature of some diseases associated with microbiome distortions is considered. Information on the tasks of human microbiome projects is presented.

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