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Metabolite Transporters as Regulators of Immunity

Authors
  • Weiss, Hauke J.
  • Angiari, Stefano
Type
Published Article
Journal
Metabolites
Publisher
MDPI
Publication Date
Oct 19, 2020
Volume
10
Issue
10
Identifiers
DOI: 10.3390/metabo10100418
PMID: 33086598
PMCID: PMC7603148
Source
PubMed Central
Keywords
License
Green

Abstract

In the past decade, the rise of immunometabolism has fundamentally reshaped the face of immunology. As the functions and properties of many (immuno)metabolites have now been well described, their exchange among cells and their environment have only recently sparked the interest of immunologists. While many metabolites bind specific receptors to induce signaling cascades, some are actively exchanged between cells to communicate, or induce metabolic reprograming. In this review, we give an overview about how active metabolite transport impacts immune cell function and shapes immunological responses. We present some examples of how specific transporters feed into metabolic pathways and initiate intracellular signaling events in immune cells. In particular, we focus on the role of metabolite transporters in the activation and effector functions of T cells and macrophages, as prototype adaptive and innate immune cell populations.

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