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Metabolism of promethazine in vitro. Identificaton of N-oxidized products.

Authors
  • Clement, B
  • Beckett, A H
Type
Published Article
Journal
Xenobiotica; the fate of foreign compounds in biological systems
Publication Date
Sep 01, 1981
Volume
11
Issue
9
Pages
609–618
Identifiers
PMID: 7314643
Source
Medline
License
Unknown

Abstract

1. Incubation of promethazine (Ia) and desmethylpromethazine (Ib) with 9000g supernatant fractions of rabbit liver homogenate resulted in formation of N-dealkylated, N-oxygenated and ring-hydroxylated products. 2. The N-oxidation products identified by t.l.c. and mass spectra using synthetic reference products are promethazine-N-oxide (IX) and the nitrone (VIII), which is believed to be formed chemically and metabolically from the metabolite N-hydroxydesmethylpromethazine (VII).

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