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Metabolism of L-canavanine and L-canaline in the tobacco budworm, Heliothis virescens [Noctuidae].

Authors
  • Berge, M A
  • Rosenthal, G A
Type
Published Article
Journal
Chemical research in toxicology
Publication Date
Jan 01, 1991
Volume
4
Issue
2
Pages
237–240
Identifiers
PMID: 1782352
Source
Medline
License
Unknown

Abstract

The metabolism of L-canavanine and L-canaline were investigated in larvae of the tobacco budworm, Heliothis virescens [Noctuidae]. H. virescens larvae were treated with L-[1,2,3,4-14C]canavanine or L-[U-14C]canaline with sufficient cold carrier to provide 5 mg g-1 canavanine or a molar equivalent of canaline (3.81 mg g-1). The preponderant catabolite in both canavanine- and canaline-treated larvae was [14C]homoserine. Other minor metabolites derived from canavanine included [14C]aspartate/asparagine, [14C]glutamate/glutamine, [14C]2-aminobutyrate, [14C]ornithine, [14C]proline, and [14C]isoleucine. Canaline yielded [14C]glutamate/glutamine, [14C]aspartate/asparagine, and [14C]-2-aminobutyrate. Our current studies support the belief that this destructive insect tolerates L-canavanine and L-canaline because of its ability to reductively cleave these potentially insecticidal natural products to L-homoserine and guanidine or ammonia, respectively.

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