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Metabolism goes viral.

Authors
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier
Volume
19
Issue
4
Pages
549–550
Identifiers
DOI: 10.1016/j.cmet.2014.03.022
Source
O'Shea Lab
License
Unknown

Abstract

Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.

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