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Metabolism of glycol-derived lipids in Novikoff hepatomas

Authors
  • Lin, Jiann-tsyh
  • Baumann, Wolfgang J.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Publication Date
Jan 01, 1974
Volume
59
Issue
1
Pages
100–107
Identifiers
DOI: 10.1016/S0006-291X(74)80180-4
Source
Elsevier
Keywords
License
Unknown

Abstract

[1,1,2,2- 2H]Ethanediol administered to Novikoff rat hepatomas was rapidly incorporated into glycol-derived neutral lipids and glycol phospholipids. The metabolic turnover rates of these diol-derived lipids and in particular of the diol phospholipids were at least an order of magnitude higher than those known for the corresponding glycerolipids. The data suggest that glycol phospholipids serve as precursors of the neutral glycol-derived lipids. Diol incorporation and diol lipid interconversions do not involve intermediary oxidation and reduction steps on the diol moiety. This was conclusively proven by mass spectrometry which showed that perdeuteration of the glycol moieties was retained in all instances.

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