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[Metabolism of exogenous phosphocreatine and 3-phosphono-2-imino-1-methyl-4-hydroxy-imidazoline in the perfused rat heart during ischemia].

Authors
Type
Published Article
Journal
Biokhimii︠a︡ (Moscow, Russia)
Publication Date
Volume
52
Issue
3
Pages
437–445
Identifiers
PMID: 3580413
Source
Medline
License
Unknown

Abstract

Exogenous phosphocreatine (PCr) and its cyclic analog, 3-phosphono-2-imino-1-methyl-4-oxoimidazolidine (PIMOI) were used as protectors of ischemic myocardium. PCr was insignificantly metabolized, whereas its analog was rapidly split, resulting in the formation of creatinine and inorganic phosphate as well as of minor amounts of PCr and creatine. Exogenous AMP and ATP accelerated PCr breakdown; in contrast, PIMOI hydrolysis slowed down in the presence of AMP. A similar inhibitory effect was observed after treatment of hearts with 2,4-dinitrofluorobenzene. These data together with those obtained for heart homogenates point to the enzymatic nature of PIMOI hydrolysis in ischemic heart. Acidic phosphatases and 5'-nucleotidases of the heart are supposed to be involved in this process.

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