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The metabolism of EGYT-475, a new antidepressant agent, in rats.

Authors
  • Guttmann, A
  • Nagy, J
  • Magyar, K
Type
Published Article
Journal
Polish journal of pharmacology and pharmacy
Publication Date
Jan 01, 1987
Volume
39
Issue
2
Pages
123–128
Identifiers
PMID: 3432157
Source
Medline
License
Unknown

Abstract

The metabolites of EGYT-475 excreted by the kidney were studied in rats using radioactive analogues of the compound tested. 40% of the total radioactivity was found in rat urine which was collected over 48 h, pooled, centrifuged, membrane-filtered, and from which the metabolites were separated by combined chromatographic procedures or extracted after acidic hydrolysis. Gas chromatographic and GC/MS studies showed that 31.1% of the radioactivity found in urine proved to be picolinyl-piperazine, 3.7% was N-benzyl-piperazine and 28.5% of it was picolinic acid. Hippuric acid accounted for 53.2% of the radioactivity of the acid hydrolyzed urine.

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