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Metabolism of androgens in rat pituitary gland and hypothalamus: catabolism of dihydrotestosterone or transformation of androgen signal?

Authors
  • Degtyar', V G
  • Kushlinskii, N E
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
May 01, 2000
Volume
129
Issue
5
Pages
407–412
Identifiers
PMID: 10977935
Source
Medline
License
Unknown

Abstract

The role of androgen metabolism and individual androgen metabolites in rat pituitary gland and hypothalamus is discussed on the basis of published data and results of our experiments. It is proposed that metabolism of androgens in these structures is aimed at the formation of not only true sex steroids estradiol-17 beta and 5 alpha-dihydrotestosterone, but also of androgens contributing to the regulation of cell processes, i.e. represents modification (transformation) of androgen signal (testosterone) in target pituitary and hypothalamic cells.

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