Metabolism and Cancer: Old and New Players

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Metabolism and Cancer: Old and New Players

Published Article
International Journal of Cell Biology
Hindawi Limited
Publication Date
Aug 23, 2013
DOI: 10.1155/2013/293201


Hindawi Publishing Corporation International Journal of Cell Biology Volume 2013, Article ID 293201, 2 pages Editorial Metabolism and Cancer: Old and New Players Claudia Cerella,1 Carine Michiels,2 Roderick H. Dashwood,3 Young-Joon Surh,4 and Marc Diederich4 1 Laboratoire de Biologie Mole´culaire et Cellulaire du Cancer (LBMCC), Hoˆpital Kirchberg, 9 rue Edward Steichen, L-2540 Luxembourg, Luxembourg 2 Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Science (NARILIS), University of Namur, 5000 Namur, Belgium 3Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis, OR 97331, USA 4Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea Correspondence should be addressed to Claudia Cerella; [email protected] Received 9 June 2013; Accepted 9 June 2013 Copyright © 2013 Claudia Cerella et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Altered metabolism represents one of the oldest hallmarks associated with cancer. The aberrant metabolic profile deals primarily with the well-known switch of transformed cells towards aerobic glycolysis from mitochondrial oxidative phosphorylation. In addition, it deals with the exacerba- tion of several biosynthetic pathways interconnected with the increased glycolytic flux, eventually conferring selective metabolic advantages. The distinctive and ubiquitous nature of this altered metabolic profile expressed by cancer cells from various origins or tissues turns the modulation/reversion of these aberrations as an amenable strategy for new anticancer therapies. Despite Otto Warburg’s pioneering observations, targeting cancer cell metaboli

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