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The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria

Authors
  • Belhayara, Mohammed Ilyes1
  • Mellouk, Zoheir1
  • Hamdaoui, Mohammed Seddik2
  • Bachaoui, Malika2
  • Kheroua, Omar1
  • Malaisse, Willy J.3
  • 1 (O.K.)
  • 2 (M.B.)
  • 3 Department of Biochemistry, Université Libre de Bruxelles, B-1070 Brussels, Belgium
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Mar 10, 2020
Volume
12
Issue
3
Identifiers
DOI: 10.3390/nu12030727
PMID: 32164195
PMCID: PMC7146633
Source
PubMed Central
Keywords
License
Green

Abstract

Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and management of MetS in young adults of Western Algeria. We studied a total of one hundred subjects aged between thirty and forty years with MetS, in which anthropometric measurements, insulin resistance, C peptide and HbA1c, lipid profile, circulating adipokines and glucagon-like peptide-1 were measured by suitable methods, in comparison to two groups of control. MetS is closely linked to altered glucose homeostasis, the plasma insulin/glucose ratio; i.e., the insulinogenic index helps to estimate the level of insulin secretion and also for assessing β-cell function. The correlation between homeostasis model assessment insulin resistance index (HOMA-IR) and HbA1c, body mass index or plasma triglycerides yielded positive and significant values. Biomarkers with a known and predictable association with MetS can provide a means to detect those at risk and intervene as needed. This could significantly decrease the burden complications impose on patients and the healthcare system.

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