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The metabolic syndrome, depression, and cardiovascular disease: interrelated conditions that share pathophysiologic mechanisms.

Authors
  • Gans, Rijk O B
Type
Published Article
Journal
The Medical clinics of North America
Publication Date
Jul 01, 2006
Volume
90
Issue
4
Pages
573–591
Identifiers
PMID: 16843763
Source
Medline
License
Unknown

Abstract

This article introduces the metabolic syndrome as a clinical phenotype with consequences for diagnosis and treatment that go beyond the different clinical specialties involved. A life-course approach is suggested as a means of understanding the complex interrelations between the metabolic syndrome, depression, and cardiovascular disease. Pathophysiologic mechanisms that these conditions share are discussed in detail. These considerations provide arguments for a more integrative approach to patients in general that surpass the current disease-centered services such as endocrinology, psychiatry, and cardiology.

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