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Metabolic and secretory response of tumoral-insulin producing cells to D-fructose and D-galactose.

Authors
  • Giroix, M H
  • Blachier, F
  • Sener, A
  • Malaisse, W J
Type
Published Article
Journal
Molecular and cellular biochemistry
Publication Date
Apr 01, 1987
Volume
74
Issue
2
Pages
163–171
Identifiers
PMID: 3037306
Source
Medline
License
Unknown

Abstract

At variance with normal islet cells, tumoral insulin-producing cells of the RINm5F line were found to display a positive secretory response not solely to D-glucose and D-mannose, but also to D-fructose and D-galactose. All hexoses increased the ATP/ADP ratio, exerted a sparing action upon the oxidation of endogenous nutrients in cells prelabelled with either L-[U-14C]glutamine or [U-14C]palmitate, increased the output of lactic acid and, as judged from data collected in the presence of D-[U-14C]hexoses, underwent oxidation in the RINm5F cells. The secretory response to these four hexoses appeared commensurate with the extent of their metabolic effects.

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