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Metabolic regulation of tumor cells exposed to different oxygenated polycyclic aromatic hydrocarbons.

Authors
  • Gao, Rui1
  • Jiang, Zihao2
  • Wu, Xiuyu3
  • Cai, Zhihong3
  • Sang, Nan4
  • 1 School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, PR China; College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. , (China)
  • 2 School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, PR China. , (China)
  • 3 College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. , (China)
  • 4 College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. Electronic address: [email protected]. , (China)
Type
Published Article
Journal
The Science of the total environment
Publication Date
Jan 10, 2024
Volume
907
Pages
167833–167833
Identifiers
DOI: 10.1016/j.scitotenv.2023.167833
PMID: 37839476
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of polycyclic aromatic derivatives with oxygen-containing functional groups that induce oxidative stress and mutations. However, studies of the carcinogenic and metabolic effects of OPAHs are limited. In this study, we analyzed the carcinogenic effects of four different OPAHs and found that 9-fluorenone (FLO), 9,10-anthraquinone (AQ), and 7,12-benz(a)anthraquinone (BAQ) promoted cell invasion and metastasis via epithelial-mesenchymal transition (EMT) and induced endothelial cell angiogenesis by affecting the expression of vascular endothelial growth factor (VEGF), angiopoietin (ANG), and platelet-derived growth factor (PDGF), whereas 1,8-naphthalic anhydride (NAD) did not show significant carcinogenic effects. In addition, combined with metabolomic analysis, we found that the tumor-promoting effects of different OPAHs were related to their effects on the metabolome, especially the metabolism of glutathione related to oxidative stress. These results provide an experimental basis for studying the carcinogenic and metabolic effects of OPAHs, and an important reference for comprehensively assessing the ecological and health risks of this compounds. Copyright © 2023 Elsevier B.V. All rights reserved.

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