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Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing.

Authors
  • Li, Pei-Heng1
  • Zhang, Ran2
  • Cheng, Li-Qin3
  • Liu, Jin-Jing4
  • Chen, Hou-Zao5
  • 1 Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. , (China)
  • 2 Buck Institute for Research on Ageing, Novato, United States. , (United States)
  • 3 Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 4 Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China. Electronic address: [email protected] , (China)
  • 5 State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Ageing research reviews
Publication Date
Sep 05, 2020
Pages
101165–101165
Identifiers
DOI: 10.1016/j.arr.2020.101165
PMID: 32898718
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The process of ageing includes molecular changes within cells and interactions between cells, eventually resulting in age-related diseases. Although various cells (immune cells, parenchymal cells, fibroblasts and endothelial cells) in tissues secrete proinflammatory signals in age-related diseases, immune cells are the major contributors to inflammation. Many studies have emphasized the role of metabolic dysregulation in parenchymal cells in age-related inflammatory diseases. However, few studies have discussed metabolic modifications in immune cells during ageing. In this review, we introduce the metabolic dysregulation of major nutrients (glucose, lipids, and amino acids) within immune cells during ageing, which leads to dysfunctional NAD + metabolism that increases immune cell senescence and leads to the acquisition of the corresponding senescence-associated secretory phenotype (SASP). We then focus on senescent immune cell interactions with parenchymal cells and the extracellular matrix and their involvement in angiogenesis, which lead to proinflammatory microenvironments in tissues and inflammatory diseases at the systemic level. Elucidating the roles of metabolic modifications in immune cells during ageing will provide new insights into the mechanisms of ageing and therapeutic directions for age-related inflammatory diseases. Copyright © 2020. Published by Elsevier B.V.

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