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Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies.

Authors
  • Cao, Lei1
  • Kwara, Awewura2
  • Greenblatt, David J1, 3
  • 1 Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA.
  • 2 Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
  • 3 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Dec 01, 2017
Volume
69
Issue
12
Pages
1762–1772
Identifiers
DOI: 10.1111/jphp.12812
PMID: 28872689
Source
Medline
Keywords
License
Unknown

Abstract

Inhibition of human CYP activity by luteolin and quercetin occurred with IC50 values exceeding customary in-vivo human exposure with tolerable supplemental doses of these compounds. The findings indicate that luteolin and quercetin are not likely to be of clinical value for preventing or treating APAP-induced hepatotoxicity.

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