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Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate.

Authors
Type
Published Article
Journal
American Journal of Clinical Nutrition
1938-3207
Publisher
Oxford University Press
Publication Date
Volume
90
Issue
6
Pages
1586–1592
Identifiers
DOI: 10.3945/ajcn.2009.27514
PMID: 19726595
Source
Medline
License
Unknown

Abstract

Low vitamin B-12 is associated with more pronounced metabolic evidence of vitamin B-12 deficiency when folate is elevated than when folate is not elevated. These data should be considered when assessing the potential costs, risks, and benefits of folic acid and vitamin B-12 fortification programs.

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