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Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate.

Authors
  • Miller, Joshua W
  • Garrod, Marjorie G
  • Allen, Lindsay H
  • Haan, Mary N
  • Green, Ralph
Type
Published Article
Journal
American Journal of Clinical Nutrition
Publisher
Oxford University Press
Publication Date
Dec 01, 2009
Volume
90
Issue
6
Pages
1586–1592
Identifiers
DOI: 10.3945/ajcn.2009.27514
PMID: 19726595
Source
Medline
License
Unknown

Abstract

Low vitamin B-12 is associated with more pronounced metabolic evidence of vitamin B-12 deficiency when folate is elevated than when folate is not elevated. These data should be considered when assessing the potential costs, risks, and benefits of folic acid and vitamin B-12 fortification programs.

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