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Metabolic effects of the association Berberis aristata/Silybum marianum: a preliminary double-blind, placebo-controlled study in obese patients with type 2 diabetes

Authors
  • Guarino, Giuseppina1
  • Della Corte, Teresa1
  • Sofia, Morena1
  • Carbone, Lucia1
  • Marino, Giampiero1
  • Martedì, Emilia2
  • Gentile, Sandro1
  • 1 Second University of Naples, Department of Experimental and Clinical Medicine, Naples, Italy , Naples (Italy)
  • 2 Diabetes Unit A.I.D. Portici, Naples, Italy , Naples (Italy)
Type
Published Article
Journal
Nutrafoods
Publisher
Springer Milan
Publication Date
Dec 11, 2015
Volume
14
Issue
4
Pages
181–188
Identifiers
DOI: 10.1007/s13749-015-0052-7
Source
Springer Nature
Keywords
License
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Abstract

Berberine, a quaternary isoquinoline alkaloid present in Berberis aristata, is well known in terms of its cholesterol-lowering, hypoglycemic, and insulinsensitizer effects. Because of its low oral bioavailability, it has been recently formulated along with silymarin (Silybum marianum) to improve intestinal absorption. The aim of our study was to evaluate, versus placebo treatment, the possible effect of its association with silymarin on abdominal fat in overweight/obese patients affected by type 2 diabetes mellitus. Using bioelectrical impedance at enrolment and after 6 months of treatment, we have evaluated the following clinical parameters: waist circumference, trunk fat, and visceral fat. Our results seem to indicate a clinically significant effect for the association berberine+silymarin.

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