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Metabolic connectivity as index of verbal working memory.

Authors
  • Zou, Na
  • Chetelat, Gael
  • Baydogan, Mustafa G
  • Li, Jing
  • Fischer, Florian U
  • Titov, Dmitry
  • Dukart, Juergen
  • Fellgiebel, Andreas
  • Schreckenberger, Mathias
  • Yakushev, Igor
Type
Published Article
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Publication Date
Jul 01, 2015
Volume
35
Issue
7
Pages
1122–1126
Identifiers
DOI: 10.1038/jcbfm.2015.40
PMID: 25785830
Source
Medline
License
Unknown

Abstract

Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.

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