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Metabolic approach for regulation of IL-1 beta in vivo.

Authors
  • Yang, T
  • Zhu, X
  • Shen, B
  • Xu, W
Type
Published Article
Journal
Science in China. Series B, Chemistry, life sciences & earth sciences
Publication Date
Mar 01, 1995
Volume
38
Issue
3
Pages
345–351
Identifiers
PMID: 7766316
Source
Medline
License
Unknown

Abstract

IL-1 beta, the autoantibodies to IL-1 beta and IL-1 beta-containing immune complex in pleural effusion and cerebrospinal fluid were detected using anti-recombinant human IL-1 beta monoclonal antibody. The results indicate that IL-1 beta is detectable in some cases, and the amounts decrease gradually with the chemotherapy following the autoantibodies and the specific detectable immune complex. These autoantibodies may have a feedback effect, inhibiting the IL-1 beta activity, and forming the immune complex to speed the clearance of activated IL-1 beta.

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