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[Metabolic adaptation to hypoxia: chronic obstructive pulmonary disease and high altitude].

Authors
  • Guinot-Bourquin, Sofia L
  • Raguso, Comasia A
  • Pichard, Claude
Type
Published Article
Journal
Revue médicale de la Suisse romande
Publication Date
Oct 01, 2004
Volume
124
Issue
10
Pages
629–634
Identifiers
PMID: 15573508
Source
Medline
License
Unknown

Abstract

The effect of oxygen in modulating metabolism has been largely investigated in vitro and in animal studies, but very little in humans. Body weight loss and muscle fatigability is a common finding in chronic obstructive pulmonary diseases, often difficult to reverse despite an optimal nutritional intake. The aim of this paper is to review recent literature regarding pathological and physiological situations characterized by hypoxia exposure, particularly chronic obstructive pulmonary diseases and high altitude staying.

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