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Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions

Authors
  • Zárate-Potes, Alejandra
  • Ali, Irtiqa
  • Ribeiro Camacho, Margarida
  • Brownless, Hayley
  • Benedetto, Alexandre
Type
Published Article
Journal
Frontiers in Microbiology
Publisher
Frontiers Media SA
Publication Date
May 10, 2022
Volume
13
Identifiers
DOI: 10.3389/fmicb.2022.853629
Source
Frontiers
Keywords
Disciplines
  • Microbiology
  • Original Research
License
Green

Abstract

Graphical abstract of the approach employed in this study. Combined analyses of C. elegans-microbe transcriptomics (1) and gene tissue expression maps (2), with high-throughput stress and infection assays following host-gene inactivation (3), can guide predictions and accelerate identification of genetic interactions involved in nematode-microbe interactions.

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