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META060 inhibits multiple kinases in the NF-kappaB pathway and suppresses LPS--mediated inflammation in vitro and ex vivo.

Authors
  • Desai, A
  • Konda, V R
  • Darland, G
  • Austin, M
  • Prabhu, K S
  • Bland, J S
  • Carroll, B J
  • Tripp, M L
Type
Published Article
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Publication Date
May 01, 2009
Volume
58
Issue
5
Pages
229–234
Identifiers
DOI: 10.1007/s00011-008-8162-y
PMID: 19169645
Source
Medline
License
Unknown

Abstract

Without inhibiting COX-2 enzyme, META060 reduces the inflammation by inhibiting multiple kinases involved in NF-kappaB pathway, and may have potential as a safe anti-inflammatory therapeutic.

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