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MET signalling: principles and functions in development, organ regeneration and cancer.

Authors
  • Trusolino, Livio
  • Bertotti, Andrea
  • Comoglio, Paolo M
Type
Published Article
Journal
Nature Reviews Molecular Cell Biology
Publisher
Springer Nature
Publication Date
Dec 01, 2010
Volume
11
Issue
12
Pages
834–848
Identifiers
DOI: 10.1038/nrm3012
PMID: 21102609
Source
Medline
License
Unknown

Abstract

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue remodelling, which underlies developmental morphogenesis, wound repair, organ homeostasis and cancer metastasis, by integrating growth, survival and migration cues in response to environmental stimuli or cell-autonomous perturbations. The versatility of MET-mediated biological responses is sustained by qualitative and quantitative signal modulation. Qualitative mechanisms include the engagement of dedicated signal transducers and the subcellular compartmentalization of MET signalling pathways, whereas quantitative regulation involves MET partnering with adaptor amplifiers or being degraded through the shedding of its extracellular domain or through intracellular ubiquitylation. Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression.

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