The paper describes a numerical interpretation of the April 2007 CarboEurope Regional Experiment Strategy (CERES) campaign, devotedto the study of CO2 cycle at the regional scale. The four consecutive clear sky days with intensive observations of CO2 concentration, 5 fluxes at the the surface and in the boundary layer have been simulated with the Meso-NH mesoscale model. Aircraft observations of CO2 have been used to identify surface modelling errors and to calibrate the CO2 components of the surface model. After this calibration, the paper describes a systematic comparison of the model outputs with all the data collected during CERES, in April 2007. As a 10 conclusion, an example of CO2 budgeting from the mesoscale model is given.