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Mesenchymal stromal cells as conductors of adipose tissue remodeling.

Authors
  • Cannavino, Jessica1
  • Gupta, Rana K1
  • 1 Department of Medicine, Division of Endocrinology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina 27701, USA [email protected] [email protected].
Type
Published Article
Journal
Genes & development
Publication Date
Sep 01, 2023
Volume
37
Issue
17-18
Pages
781–800
Identifiers
DOI: 10.1101/gad.351069.123
PMID: 37798016
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response to changes in physiological and environmental conditions. Here, we describe recent advances in our understanding of how functionally distinct tissue-resident mesenchymal stromal cell subpopulations orchestrate several aspects of physiological and pathophysiological adipose tissue remodeling, with a particular focus on the adaptations that occur in response to changes in energy surplus and environmental temperature. The study of adipose tissue remodeling provides a vehicle to understand the functional diversity of stromal cells and offers a lens through which several generalizable aspects of tissue reorganization can be readily observed. © 2023 Cannavino and Gupta; Published by Cold Spring Harbor Laboratory Press.

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