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Mesenchymal stem cells home to inflamed ocular surface and suppress allosensitization in corneal transplantation.

Authors
  • Omoto, Masahiro
  • Katikireddy, Kishore R
  • Rezazadeh, Alexandra
  • Dohlman, Thomas H
  • Chauhan, Sunil K
Type
Published Article
Journal
Investigative Opthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Oct 01, 2014
Volume
55
Issue
10
Pages
6631–6638
Identifiers
DOI: 10.1167/iovs.14-15413
PMID: 25228546
Source
Medline
Keywords
License
Unknown

Abstract

Our data demonstrate that systemically administered MSCs specifically home to the inflamed ocular surface and promote allograft survival by inhibiting APC maturation and induction of alloreactive T cells.

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