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Mesenchymal stem cells in allergic diseases: Current status.

Authors
  • Li, He1
  • Tian, Yunzhe1
  • Xie, Lihui1
  • Liu, Xiuxing1
  • Huang, Zhaohao1
  • Su, Wenru2
  • 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. , (China)
  • 2 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Allergology international : official journal of the Japanese Society of Allergology
Publication Date
Aug 21, 2019
Identifiers
DOI: 10.1016/j.alit.2019.08.001
PMID: 31445840
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Allergic diseases, which include asthma, allergic skin diseases, allergic rhinitis and allergic conjunctivitis, have already garnered worldwide public health attention over recent decades. Mesenchymal stem cells (MSCs) have gradually emerged as a potential method for treating allergic diseases due to their immunosuppressive characteristics, tissue repair ability and secretion of various biological factors. This potential of MSC-based therapy has been confirmed in clinical and preclinical studies, which report the therapeutic benefits of MSCs for various allergic diseases and explore the antiallergic mechanisms. In this review, we focus on the discoveries and biological mechanisms of MSCs as a therapeutic tool in allergic diseases. We discuss the challenges of conducting MSC studies as well as future directions. Copyright © 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.

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