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Streptococcus gordonii: Pathogenesis and Host Response to Its Cell Wall Components.

Authors
  • Park, Ok-Jin1
  • Kwon, Yeongkag1
  • Park, Chaeyeon1
  • So, Yoon Ju1
  • Park, Tae Hwan1
  • Jeong, Sungho1
  • Im, Jintaek1
  • Yun, Cheol-Heui2, 3
  • Han, Seung Hyun1
  • 1 Department of Oral Microbiology and Immunology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul 08826, Korea. , (North Korea)
  • 2 Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea. , (North Korea)
  • 3 Institute of Green Bio Science Technology, Seoul National University, Pyeongchang 25354, Korea. , (North Korea)
Type
Published Article
Journal
Microorganisms
Publisher
MDPI AG
Publication Date
Nov 24, 2020
Volume
8
Issue
12
Identifiers
DOI: 10.3390/microorganisms8121852
PMID: 33255499
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Streptococcus gordonii, a Gram-positive bacterium, is a commensal bacterium that is commonly found in the skin, oral cavity, and intestine. It is also known as an opportunistic pathogen that can cause local or systemic diseases, such as apical periodontitis and infective endocarditis. S. gordonii, an early colonizer, easily attaches to host tissues, including tooth surfaces and heart valves, forming biofilms. S. gordonii penetrates into root canals and blood streams, subsequently interacting with various host immune and non-immune cells. The cell wall components of S. gordonii, which include lipoteichoic acids, lipoproteins, serine-rich repeat adhesins, peptidoglycans, and cell wall proteins, are recognizable by individual host receptors. They are involved in virulence and immunoregulatory processes causing host inflammatory responses. Therefore, S.gordonii cell wall components act as virulence factors that often progressively develop diseases through overwhelming host responses. This review provides an overview of S. gordonii, and how its cell wall components could contribute to the pathogenesis and development of therapeutic strategies.

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