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The mental health of Chinese women with polycystic ovary syndrome is related to sleep disorders, not disease status.

Authors
  • Yang, Yin1
  • Deng, Hui2
  • Li, Tian3
  • Xia, Min4
  • Liu, Chang5
  • Bu, Xiao-Qing1
  • Li, Hang4
  • Fu, Li-Juan6
  • Zhong, Zhao-Hui7
  • 1 Department of Epidemiology, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China. , (China)
  • 2 Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. , (China)
  • 3 The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. , (China)
  • 4 Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China. , (China)
  • 5 Joint International Research Laboratory of Reproduction and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing, China. , (China)
  • 6 Department of Herbal Medicine, School of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.. Electronic address: [email protected] , (China)
  • 7 Department of Epidemiology, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of affective disorders
Publication Date
Mar 01, 2021
Volume
282
Pages
51–57
Identifiers
DOI: 10.1016/j.jad.2020.12.084
PMID: 33388474
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mental health disorders are highly prevalent in polycystic ovary syndrome (PCOS) cases. The etiology for anxiety/depression in women with PCOS still remains unclear, due to conflicting results. To examine whether an association exists between the mental health of Chinese women with PCOS and various indicators such as their disease characteristics, biochemistry results and sleep status. During July 2018 and January 2020, our study included a total of 433 women diagnosed with PCOS at Chongqing Hospital of Traditional Chinese Medicine. Sleep-related variables were evaluated by the Pittsburgh Sleep Quality Index (PSQI), anxiety and depression values were quantified by the Hospital Anxiety and Depression Scale (HADS), and biochemistry results were collected from the medical records of the patients. 26.6% patients resulted as positive anxiety and 23.6% as positive depression. We found significant associations between anxiety/depression status and sleep conditions of PCOS patients. More specifically, anxiety significantly associated with sleep quality OR (95%CI) = 1.611 (1.147-2.261), sleep disturbance 2.326 (1.468-3.685) and daytime dysfunction 1.457 (1.122-1.891). Similarly, depression significantly associated with sleep quality 1.467 (1.043-2.063), sleep disturbance 1.624 (1.030-2.561) and daytime dysfunction 1.406 (1.077-1.836). There was no association detected between mental health and disease characteristics, as well as reproductive and metabolic indicators in PCOS. Cross-sectional nature of the data prevents causal associations, selection bias of a hospital-based population. Sleep-related disorders might be involved in the etiology and development of the anxiety/depression observed in PCOS cases. We propose that management of sleep disorders should be an integral part of the disease management of women with PCOS. Copyright © 2020. Published by Elsevier B.V.

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