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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Authors
  • Gebhardt, Thomas1
  • Wakim, Linda M1
  • Eidsmo, Liv1
  • Reading, Patrick C1
  • Heath, William R1
  • Carbone, Francis R1
  • 1 The University of Melbourne, Melbourne, Victoria, Australia , Melbourne (Australia)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Mar 22, 2009
Volume
10
Issue
5
Pages
524–530
Identifiers
DOI: 10.1038/ni.1718
Source
Springer Nature
License
Yellow

Abstract

Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.

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