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Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex.

Authors
Type
Published Article
Journal
Science
0036-8075
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Volume
291
Issue
5512
Pages
2417–2419
Identifiers
PMID: 11264539
Source
Medline

Abstract

The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of long-term CTA memory depends on muscarinic and beta-adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and beta-adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This resembles the molecular signature of the formation of long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with learning, but the mechanisms of learning anew differ from those of learning the new.

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