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Membrane and nuclear initiated estrogenic regulation of homeostasis.

Authors
  • Stincic, Todd L1
  • Rønnekleiv, Oline K2
  • Kelly, Martin J3
  • 1 Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States. , (United States)
  • 2 Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States. , (United States)
  • 3 Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Steroids
Publication Date
Apr 01, 2021
Volume
168
Pages
108428–108428
Identifiers
DOI: 10.1016/j.steroids.2019.108428
PMID: 31229508
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Reproduction and energy balance are inextricably linked in order to optimize the evolutionary fitness of an organism. With insufficient or excessive energy stores a female is liable to suffer complications during pregnancy and produce unhealthy or obesity-prone offspring. The quintessential function of the hypothalamus is to act as a bridge between the endocrine and nervous systems, coordinating fertility and autonomic functions. Across the female reproductive cycle various motivations wax and wane, following levels of ovarian hormones. Estrogens, more specifically 17β-estradiol (E2), coordinate a triumvirate of hypothalamic neurons within the arcuate nucleus (ARH) that govern the physiological underpinnings of these behavioral dynamics. Arising from a common progenitor pool of cells, this triumvirate is composed of the kisspeptin (Kiss1ARH), proopiomelanocortin (POMC), and neuropeptide Y/agouti-related peptide (AgRP) neurons. Although the excitability of these neuronal subpopulations is subject to genomic and rapid estrogenic regulation, kisspeptin neurons are the most sensitive, reflecting their integral function in female fertility. Based on the premise that E2 coordinates autonomic functions around reproduction, we will review the recent findings on the synaptic interactions between Kiss1, AgRP and POMC neurons and how the rapid membrane-initiated and intracellular signaling cascades activated by E2 in these neurons are critical for control of homeostatic functions supporting reproduction. Copyright © 2019 Elsevier Inc. All rights reserved.

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