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Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury.

Authors
  • Slone, Emily Archer1
  • Fleming, Sherry D2
  • 1 College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. Electronic address: [email protected]
  • 2 Division of Biology, Kansas State University, Manhattan, KS 66506, USA. Electronic address: [email protected]
Type
Published Article
Journal
Clinical Immunology
Publisher
Elsevier
Publication Date
July 2014
Volume
153
Issue
1
Pages
228–240
Identifiers
DOI: 10.1016/j.clim.2014.04.018
PMID: 24814240
Source
Medline
Keywords
License
Unknown

Abstract

Ischemia, lack of blood flow, and reperfusion, return of blood flow, are a common phenomenon affecting millions of Americans each year. Roughly 30,000 Americans per year experience intestinal ischemia-reperfusion (IR), which is associated with a high mortality rate. Previous studies of the intestine established a role for neutrophils, eicosanoids, the complement system and naturally occurring antibodies in IR-induced pathology. Furthermore, data indicate involvement of a lipid or lipid-like moiety in mediating IR-induced damage. It has been proposed that antibodies recognize exposure of neo-antigens, triggering action of the complement cascade. While it is evident that the pathophysiology of IR-induced injury is complex and multi-factorial, we focus this review on the involvement of eicosanoids, phospholipids and neo-antigens in the early pathogenesis. Lipid changes occurring in response to IR, neo-antigens exposed and the role of a phospholipid transporter, phospholipid scramblase 1 will be discussed.

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