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Melatonin improves liver function in benzene-treated rats.

Authors
  • Sharma, Seema
  • Rana, Suresh Vir Singh
Type
Published Article
Journal
Archives of Industrial Hygiene and Toxicology
Publisher
De Gruyter Open Sp. z o.o.
Publication Date
Jun 01, 2013
Volume
64
Issue
2
Pages
33–41
Identifiers
DOI: 10.2478/10004-1254-64-2013-2248
PMID: 23819930
Source
Medline
License
Unknown

Abstract

In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzene-treated rats thanks to its antioxidative properties.

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