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Melanotropic peptides in the mammalian brain: the melanin-concentrating hormone.

Authors
Type
Published Article
Journal
Peptides
0196-9781
Publisher
Elsevier
Publication Date
Volume
17
Issue
6
Pages
1063–1073
Identifiers
PMID: 8899828
Source
Medline
License
Unknown

Abstract

Melanin-concentrating hormone (MCH) has been identified in neurons of the mammalian brain. This review summarizes some current information regarding the cell biology of this neuropeptide and the topography of MCH-immunoreactive (-IR) neurons in several species including mouse, rat, hamster, guinea pig, rabbit, dog and monkey; and atlas of MCH-IR neurons in the hypothalamus and subthalamus of the brain of guinea pig is presented. Based upon the location of this MCH cell group, it is hypothesized that they may be functionally involved in circuits of extrapyramidal motor systems from striatal centers to the thalamus and cerebral cortex and to the midbrain and spinal cord.

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