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Melanotic neuroectodermal tumor of infancy with high serum levels of alpha-fetoprotein. Ultrastructural study and immunological evidence of glial fibrillary protein and alpha-fetoprotein.

Authors
  • Dourov, N
  • Mayer, R
  • de Martelaere, F
  • Godart, S
  • Gepts, W
  • Maurus, R
Type
Published Article
Journal
Journal of oral pathology
Publication Date
May 01, 1987
Volume
16
Issue
5
Pages
251–255
Identifiers
PMID: 2443628
Source
Medline
License
Unknown

Abstract

We report an infant melanotic neuroectodermal tumor in the anterior part of the upper gingiva, which was associated with high urinary excretion of vanilmandelic acid. Serum levels of alpha-fetoprotein were abnormally high (200 ng/ml). They returned to normal after removal of the tumor (10 ng/ml). The tumor was characterized histologically and ultrastructurally by the presence of melanocytic and astrocytic cells containing glial fibrillary protein. Intracellular alpha-fetoprotein was demonstrated by the immunoperoxidase method (PAP) in scattered foci of interstitial cells.

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