Affordable Access

Melanotic ependymoma and subependymoma.

Authors
  • Rosenblum, M K
  • Erlandson, R A
  • Aleksic, S N
  • Budzilovich, G N
Type
Published Article
Journal
The American Journal of Surgical Pathology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 1990
Volume
14
Issue
8
Pages
729–736
Identifiers
PMID: 2378394
Source
Medline
License
Unknown

Abstract

We report two examples of melanin production by human gliomas. One was a grossly pigmented, well-differentiated ependymoma resected from the left frontoparietal region of a 13-year-old girl. The patient received radiotherapy and was free of tumor 12 years after operation. The second example was a pigmented subependymoma incidentally discovered at the autopsy of a 52-year-old man. Neoplastic cells containing an intracytoplasmic pigment satisfying histochemical criteria for melanin were present in both cases. Electron microscopic study of the melanotic ependymoma revealed electron-dense granules in the cytoplasm of cells forming rosettes. Premelanosomes were not detected. While the mechanism of melanogenesis in these cases is obscure, they support the potential of glial derivatives to produce melanin and indicate that melanogenesis in such neoplasms may have no adverse prognostic import.

Report this publication

Statistics

Seen <100 times