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Melanoma Adjuvant Therapy

Authors
  • Tarhini, Ahmad A.
  • Thalanayar, Prashanth M.1
  • 1 University of Pittsburgh Cancer Institute
Type
Published Article
Journal
Hematology/Oncology Clinics of North America
Publisher
Elsevier
Publication Date
Jan 01, 2014
Identifiers
DOI: 10.1016/j.hoc.2014.02.004
Source
Elsevier
Keywords
License
Unknown

Abstract

Adjuvant therapy targets melanoma micrometastases in patients with surgically resected disease that carry a high risk of death from melanoma recurrence. In this setting, adjuvant therapy provides the greatest opportunity for cure before progression into advanced inoperable stages. In randomized clinical trials, interferon-α has been shown to have a significant impact on relapse free survival and at high dosage on overall survival as compared to observation (E1684) and the GMK vaccine (E1694). Here, we review melanoma adjuvant therapy along with the on-going and planned clinical trials.

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