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Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?

Authors
  • Bolden, Ashley L1
  • Rochester, Johanna R2
  • Kwiatkowski, Carol F3
  • 1 The Endocrine Disruption Exchange (TEDX), Paonia CO, United States(1). Electronic address: [email protected] , (United States)
  • 2 The Endocrine Disruption Exchange (TEDX), Paonia CO, United States(1). , (United States)
  • 3 The Endocrine Disruption Exchange (TEDX), Paonia CO, United States(1); Department of Integrative Physiology, University of Colorado, Boulder, CO, United States. , (United States)
Type
Published Article
Journal
Toxicology letters
Publication Date
Oct 05, 2017
Volume
280
Pages
181–189
Identifiers
DOI: 10.1016/j.toxlet.2017.07.893
PMID: 28751210
Source
Medline
Keywords
License
Unknown

Abstract

Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and in vitro findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.

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