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Meiotic spindle assembly checkpoint and aneuploidy in males versus females

Authors
  • Lane, Simon
  • Kauppi, Liisa
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Dec 18, 2018
Volume
76
Issue
6
Pages
1135–1150
Identifiers
DOI: 10.1007/s00018-018-2986-6
Source
Springer Nature
Keywords
License
Green

Abstract

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.

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