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The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene.

Authors
  • Hari, K L
  • Santerre, A
  • Sekelsky, J J
  • McKim, K S
  • Boyd, J B
  • Hawley, R S
Type
Published Article
Journal
Cell
Publisher
Elsevier
Publication Date
Sep 08, 1995
Volume
82
Issue
5
Pages
815–821
Identifiers
PMID: 7671309
Source
Medline
License
Unknown

Abstract

The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and Mec1p proteins. There is also extensive functional overlap between mei-41 and ATM. Like ATM-deficient cells, mei-41 cells are exquisitely sensitive to ionizing radiation and display high levels of mitotic chromosome instability. We also demonstrate that mei-41 cells, like ATM-deficient cells, fail to show an irradiation-induced delay in the entry into mitosis that is characteristic of normal cells. Thus, the mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene.

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