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Mefloquine-pyrimethamine-sulfadoxine combination delays emergence of mefloquine resistant Plasmodium falciparum in continuous culture.

Authors
  • Tan-Ariya, P
  • Brockelman, C R
  • Menabandhu, C
Type
Published Article
Journal
The Southeast Asian journal of tropical medicine and public health
Publication Date
Dec 01, 1984
Volume
15
Issue
4
Pages
531–535
Identifiers
PMID: 6398918
Source
Medline
License
Unknown

Abstract

The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.

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