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Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha.

Authors
Type
Published Article
Journal
Science s STKE
Publisher
American Association for the Advancement of Science (AAAS)
Volume
2002
Issue
115
Source
Hunter Lab
License
Unknown

Abstract

Exquisite regulation is required for cells to properly enter and exit the phases of the cell cycle. The transmembrane receptor-like protein tyrosine phosphatase RPTPalpha, an important protein that participates in the transition of the cell cycle from G2 to mitosis activates the protein tyrosine kinase c-Src in vivo. Mustelin and Hunter discuss new findings that describe the highly regulated activation of RPTPalpha and c-Src that occurs just before entry into the mitotic phase. These findings also raise several questions that pertain to redistribution of RPTPalpha in the cell, and the role of phosphorylation and dimerization in regulating RPTPalpha activity.

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