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Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.

Authors
  • Mariotti, François
  • Hammiche, Alexia
  • Blouet, Clémence
  • Daré, Sophie
  • Tomé, Daniel
  • Huneau, Jean François
Type
Published Article
Journal
European journal of nutrition
Publication Date
Oct 01, 2006
Volume
45
Issue
7
Pages
383–390
Identifiers
PMID: 17061018
Source
Medline
License
Unknown

Abstract

In a context of a diet rich in protein and adequate in methyl donors, rats exhibit a complex adaptation to the medium-term methionine supplementation, with improvement in blood pressure control despite marked HHcy. The lack of increase in plasma ADMA may account for the absence of detrimental effects of HHcy on hemodynamics.

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