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Medication-related pharmacological manipulations of nicotine self-administration in the rat maintained on fixed- and progressive-ratio schedules of reinforcement.

Authors
  • Coen, Kathleen M
  • Adamson, K Laurel
  • Corrigall, William A
Type
Published Article
Journal
Psychopharmacology
Publication Date
Jan 01, 2009
Volume
201
Issue
4
Pages
557–568
Identifiers
DOI: 10.1007/s00213-008-1321-6
PMID: 18795267
Source
Medline
License
Unknown

Abstract

Noradrenergic-nicotinic cholinergic interactions and enhanced responding consequent to dopamine reuptake inhibition may be part of the complex behavioral pharmacology of bupropion-like compounds. Observation of differential results with the two schedules has implication for the use of self-administration techniques to elaborate the mechanisms of dependence as well as drug discovery.

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