Background. Drug-impaired driving is a prominent road safety concern and research surrounding this issue is being conducted at an unprecedented pace. However much less is known about driving under the influence of prescription medication, and how to manage this road safety issue, especially in light of an aging population. Further research to support the development of tailored enforcement strategies and educational campaigns that address the risks associated with prescription medication use and driving is needed. Objectives. The objective of this study was to compare the rates of drivers in Canada, Europe and the United States who self-declare driving after taking medication with a warning that it may influence driving ability to determine what quantitative differences exist between these three regions. The effects of demographics and personal beliefs on this self-reported behaviour were also examined. Methods. Self-reported use of prescription medication with a warning that it may influence driving ability, and personal acceptability of this behaviour were measured as part of the E-Survey of Road Users’ Attitudes (ESRA 2; www.esranet.eu). ESRA 2 is a joint international initiative of 26 research centres and road safety institutes; the project has surveyed road users in 38 countries on 5 continents. The descriptive analysis compared rates of this self-reported behaviour and opinions regarding personal acceptability by region. A multivariate model predicting driver’s self-reported use of prescription medication with a warning that it may influence driving ability was estimated. Results. At the time of submission of this abstract, data collection for the cross-sectional online survey is ongoing. Data collection will begin in December 2018; final analysis results will be available in February, 2019.