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Medical treatment of nephrolithiasis.

Authors
  • Borghi, Loris1
  • Meschi, Tiziana
  • Schianchi, Tania
  • Allegri, Franca
  • Guerra, Angela
  • Maggiore, Umberto
  • Novarini, Almerico
  • 1 Department of Clinical Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Endocrinology and Metabolism Clinics of North America
Publisher
Elsevier
Publication Date
Dec 01, 2002
Volume
31
Issue
4
Identifiers
PMID: 12474645
Source
Medline
License
Unknown

Abstract

The medical treatment of nephrolithiasis is aimed in particular at the prevention of relapses, even though in some cases, such as cystine or uric acid lithiasis, the calculi also can be dissolved on site. When the diagnosis and metabolic profile have been performed correctly, medical treatment is effective in a large number of patients. The greatest difficulty is the patient's compliance with the most suitable prevention measures and the frequency of follow-up controls. This compliance can be influenced significantly by the amount of time that the doctor spends to explain the origin of the disease. This article reviews the main methods available for the medical treatment of various nephrolithiasis types, namely water intake, diet, and drugs, supplying the relevant information about the mechanism of action, metabolic consequences, indications, evidence provided from studies, dosage, efficacy, and side-effects. Finally, brief simplified guidelines are given for the medical treatment of stone disease caused by calcium oxalate or calcium phosphate, uric acid, cystine, and struvite.

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