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Medical and surgical interventions to improve the quality of life for endometriosis patients: a systematic review

  • D’Alterio, Maurizio Nicola1
  • Saponara, Stefania1
  • Agus, Mirian2
  • Laganà, Antonio Simone3
  • Noventa, Marco4
  • Loi, Emanuela Stochino5
  • Feki, Anis5
  • Angioni, Stefano1
  • 1 University of Cagliari, Cittadella Universitaria Blocco I Asse Didattico Medicina P2, Monserrato, Cagliari, 09042, Italy , Cagliari (Italy)
  • 2 University of Cagliari, Cagliari, Italy , Cagliari (Italy)
  • 3 University of Insubria, Varese, Italy , Varese (Italy)
  • 4 University of Padua, Padua, 35121, Italy , Padua (Italy)
  • 5 HFR Fribourg, Hôpital Cantonal, Fribourg, Switzerland , Fribourg (Switzerland)
Published Article
Gynecological Surgery
Springer Berlin Heidelberg
Publication Date
Jun 03, 2021
DOI: 10.1186/s10397-021-01096-5
Springer Nature


Endometriosis impairs the quality of life (QoL) of many women, including their social relationships, daily activity, productivity at work, and family planning. The aim of this review was to determine the instruments used to examine QoL in previous clinical studies of endometriosis and to evaluate the effect of medical and surgical interventions for endometriosis on QoL. We conducted a systematic search and review of studies published between January 2010 and December 2020 using MEDLINE. Search terms included “endometriosis” and “quality of life.” We only selected studies that used a standardized questionnaire to evaluate QoL before and after medical or surgical interventions. Only articles in the English language were examined. The initial search identified 720 results. After excluding duplicates and applying inclusion criteria, 37 studies were selected for analysis. We found that the two scales most frequently used to measure QoL were the Short Form-36 health survey questionnaire (SF-36) and the Endometriosis Health Profile-30 (EHP-30). Many medical and surgical treatments demonstrated comparable benefits in pain control and QoL improvement. There is no clear answer as to what is the best treatment for improving QoL because each therapy must be personalized for the patient and depends on the woman’s goals. In conclusion, women must be informed about endometriosis and given easily accessible information to improve treatment adherence and their QoL.

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