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Medical and surgical aspects of pediatric renal transplantation using living donors.

Authors
  • Vester, U
  • Kranz, B
  • Testa, G
  • Paul, A
  • Broelsch, C E
  • Hoyer, P F
Type
Published Article
Journal
Transplantation Proceedings
Publisher
Elsevier
Publication Date
Jun 01, 2004
Volume
36
Issue
5
Pages
1308–1310
Identifiers
PMID: 15251319
Source
Medline
License
Unknown

Abstract

The outcomes of 19 consecutive living-donor renal transplants (LD-RTx) was compared with 41 cadaveric grafts (CD-RTx) performed at our institution using basiliximab, cyclosporine, and prednisone as standard immunosuppression. LD-RTx significantly shortened the waiting time on dialysis. However, patient survival (100% in both groups), 1-year graft survival (94.7% vs 90%), and rejection-free graft survival (76.9% vs 73.5%) was not significantly different. LD-RTx showed better glomerular filtration rates in the early phase after transplantation, a difference that faded with time. Graft function was similar after 1 and 2 years. LD grafts with double renal arteries were used successfully in four cases; heparin therapy was administered to avoid graft thrombosis. A significantly greater number of lymphoceles was observed with LD grafts (7/19 vs 1/41, P < .01). In conclusion with improved immunosuppression producing better results with CD grafts, the advantages of LD-RTx have vanished. LD grafts with double arteries may be used successfully and LD-RTx allows a shorter dialysis period. The high incidence of lymphoceles in our series awaits further evaluation.

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